Ofosu Ampofo was a member of the 2nd and 3rd Parliament of the fourth republic of Ghana and a politician of the National Democratic Congress.His political career started when he was appointed District Chief Executive by His excellency former president Jerry John Rawlings from 1994 to 1996.

He then participated in the 1996 Ghanaian general elections as a parliamentary candidate for the Fanteakwa North constituency of the Eastern region of Ghana. He retained his seat in the 2000 Ghanaian general elections. He contested again in the 2004 elections and lost to Kwadjo Agyei Addo of the New Patriotic Party.

He went ahead to contest again in the 2008 Ghanaian general elections and lost again to Kwabena Amankwa Asiamah of the New Patriotic party. He stood for the party National Organizer position,and was appointed Ghana Minister for Local Government and Rural Development by President Mills during a cabinet reshuffle in January 2011.
Prior to this appointment he had been the Eastern Regional Minister since the start of the Mills NDC government in 2009 and was succeeded by Kwasi Akyem Apea-Kubi. He was later appointed board chairman of Ghana ports and Harbour Authority in 2013 under the regime of former president John Dramani Mahama.

In November 2018, Ampofo was elected the National Chairman of the NDC at 9th delegate congress held at Fantasy Dome at the Trade Fair Centre in Accra. His contenders were Dan Abodakpi, Betty Mould Iddrisu, Alhaji Huudu Yahaya and Danny Annang. Before becoming the chairman, he became the Vice Chairman in 2014.

How can someone with this perfect record be ignored. He has passed through the system and he has all the experience. Elections is not about who wears the dangerous or fearful batakari during the election day ooooo, it’s about good strategy. General has done his part for the party and we all say Ayikoo and moneye to him but this time, we are sorry we are all for the humble servant.

You can go and burn the Dansoman sea. We want a formidable party. General has a very bad intentions under his sleeves. You will regret how this man will manage the affairs of the party when he wins. That man is extremely dangerous. You can hate him or like him and he is still Chairman 1. Come and join the winning team, it’s not too late.